Wrong Turn (2003) on Netflix

Chris Finn (Desmond Harrington) is on his way to a job interview and is driving through the mountains of West Virginia. There is then a chemical spill on the road, so being short on time, he decides to take a different route, an abandoned dirt road in the middle of nowhere. He then by accident crashes into a car sitting in the middle of the road. He then meets a group of friends on a hiking trip who include Jessie (Eliza Dushku) whom where stranded on the road. Two people stay at the car, and another group goes for help, only to find a sinister cabin nesteled in the West Virgina woods, that is home to a trio of cannibalistic mountain men horribly disfigured from years of in-breeding. They then make a mad dash for their lives through out the woods, only hoping to make it out alive.