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Jon Arbuckle buys a second pet, a dog named Odie. However, Odie is then abducted and it is up to Jon's cat, Garfield, to find and rescue the canine.

Garfield, who competes with a dog named Odie for the affection and attention of their human master, Jon Arbuckle, when Odie is introduced into their home much to Garfield's disgust. When Odie runs away, he gets picked up by a mean dog trainer, however, Garfield feels responsible, so he gets off his favorite spot and gets into action to rescue his fellow pet Liz, Garfield's veterinarian and romantic interest; Cannon plays a "city mouse" who helps Garfield in his search; Messing voices Arlene, Garfield's girlfriend)

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